According to Action Comics No. 243, the legendary enchantress Circe was herself a native of the planet Krypton. She gives Superman an evolution serum, transforming him partially into a lion (Aug 1958: "The Lady and the Lion").
In November 1963, with the aid of Proty II, Saturn Woman poses as the enchantress Circe as part of Supermanâ€™s plan to defeat the Superman Revenge Squad (S No. 165/1: pts. I-II—"Beauty and the Super-Beast!"; "Circeâ€™s Super-Slave").
Apparently Circe was also active in the time of the ancients Greeks, she is responsible for changing Biron the centaur into a horse and later giving him super-powers as Comet the Super-Horse (S No. 176/1, Apr 1965: "The Revenge of the Super-Pets!").